What is Preimplantation Genetic Screening?

The couple who opt for IVF for a child generally wonders if their child would be genetically fit. This stress may be more when intended couples are genetically challenged and think that their child should not have these genetic issues. So in this blog, we are going to reveal the new advanced technique to ensure your child will be genetically fit.

PGS or Preimplantation Genetic Screening is a genetic test that has made IVF most successful than ever! Assisted reproductive treatments can now show infertility and genetic conditions more effectively than before. Couples and individuals affected by a genetic disorder can conceive a biological child. Couples or individuals at increased risk for having embryos with abnormal chromosomes are the best candidates for PGS. These include:

  1. Advanced maternal age above 35
  2. Recurrent miscarriages, or
  3. Previous failed IVF attempts

In a normal person, there are 23 pairs or 46 chromosomes present. Aneuploidy is the condition in which an embryo contains one more or one less chromosome. That means, there are 45 or 47 chromosomes present instead of the normal 46. PGS (Preimplantation Genetic Screening) screens embryos for chromosomal abnormalities (aneuploidy).


PGS test for chromosomal abnormalities. On day 3 or day 5 of embryo development, a few cells are removed from embryos created with IVF. The DNA of these cells will be evaluated for chromosomal defects. At this stage, the embryologist can determine the gender (sex) of the embryos. If parents are interested in family balancing, then only embryos of the desired sex will be transferred to the mother’s uterus.

It diagnoses single gene mutations associated with genetically inherited diseases, e.g. sickle cell anemia, muscular dystrophy, Huntington’s Disease, Fragile X syndrome, cystic fibrosisand many more.

The success rate of PGS

The chance of a successful outcome with PGS in joint with IVF treatment depends on whether any and how many of the embryos produced in an IVF cycle have a normal PGS result. According to the reports a live birth rate is high 60% to 80% when an elective single frozen embryo is transferred in a subsequent cycle. These success rates are very encouraging as most couples who undergo PGS and IVF are at higher risk of producing chromosomally abnormal embryos such as advanced maternal age, previous IVF failures, or recurrent pregnancy losses.

So, from all the above context, we can ensure you if you are worried about any means for IVF and procedures. You can visit the renowned Asha IVF and Fertility Centre, PGS clinic in Faridabad.

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